
Syrian rue, scientifically known as Peganum harmala, is a plant that has been used for centuries in various cultural and medicinal practices. Native to desert regions, it has a wide range of traditional and modern uses, from medicine to spiritual ceremonies. Syrian rue is also known as wild rue, African rue, harmal shrub, and harmel, among other names. The plant's seeds are of particular interest due to their stimulant, depressant, and
| Characteristics | Values |
|---|---|
| Common names | Syrian Rue, Wild Rue, African Rue, Esfand, Harmal, Espand, Harmel, Peganon |
| Scientific name | Peganum harmala |
| Plant type | Perennial, herbaceous plant with a woody underground rootstock |
| Plant family | Nitrariaceae or Zygophyllaceae (Caltrop family) |
| Plant height | Up to 1 meter |
| Appearance | Fragile leaves, white flowers at the end of each stalk |
| Soil type | Saline soils |
| Region | Eastern Mediterranean, Middle East, India, Mongolia, Manchuria, North America |
| Uses | Medicinal, spiritual, incense, soaps, candles, bread-making, wine-making |
| Ritual significance | Warding off the evil eye, protecting against evil, ritual inebriation |
| Active compounds | Harmala alkaloids (monoamine oxidase inhibitors), including Harmine and Harmaline |
| Side effects | Inebriation, aphrodisiac effects, MAO-inhibiting effects, analgesic, emmenagogue, abortifacient |
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What You'll Learn
- Syrian rue is a desert plant that grows in the Eastern Mediterranean, Middle East, India, Mongolia and Manchuria
- The seeds are dried and burnt as incense, with the smoke believed to ward off the evil eye
- Syrian rue is mentioned in the Quran as a sacred plant, with a long history of ritual and medicinal use
- The plant is considered a noxious weed in several countries as eating it can sicken or kill livestock
- Syrian rue is used in candle-making and soaps, and as an analgesic, emmenagogue, and abortifacient agent

Syrian rue is a desert plant that grows in the Eastern Mediterranean, Middle East, India, Mongolia and Manchuria
Syrian rue, scientifically known as Peganum harmala, is a desert plant that grows in the Eastern Mediterranean, Middle East, India, Mongolia, Manchuria, and North Africa. It is a perennial, herbaceous plant that can grow up to 0.8 meters tall, but typically reaches a height of around 0.3 meters. Syrian rue is native to a wide range of regions, including the eastern Iranian region and the Indian subcontinent. In Africa, it is found in Morocco, Algeria, Tunisia, Libya, and Egypt, while in Europe, it is native to Spain, Russia, Serbia, Moldova, Ukraine, Romania, Bulgaria, Greece, Cyprus, and southern Italy.
The plant is well-adapted to dry conditions and thrives in saline soils of temperate desert and Mediterranean regions. Syrian rue has deep roots that can reach up to 6.1 meters in depth, allowing it to access water in arid environments. It blooms between June and August in the Northern Hemisphere, producing small, white or pale yellow flowers. The seeds of Syrian rue are triangular and black-brown in color.
The plant has a variety of traditional and medicinal uses. In Turkey, the dried capsules of Syrian rue are used as talismans, and the smoke from burning the seeds is believed to treat mental illnesses. In Iran, Iraq, Tajikistan, Afghanistan, Pakistan, and India, the plant is used in traditional medicine. Syrian rue has also been used as an analgesic, emmenagogue, and abortifacient. Additionally, the ancient Greeks utilized powdered seeds to treat recurring fevers and tapeworms.
Syrian rue has been introduced to the western United States, where it was first planted in New Mexico in 1928 by a farmer aiming to produce a dye from its seeds. Since then, it has spread to Arizona, California, Montana, Nevada, Oregon, Texas, and Washington. Due to its drought tolerance, Syrian rue can outcompete native plants in the salt-desert shrub lands of the Western United States.
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The seeds are dried and burnt as incense, with the smoke believed to ward off the evil eye
Syrian rue, scientifically known as Peganum harmala, is a perennial, herbaceous plant with a woody underground rootstock. It is commonly found in saline soils in temperate desert and Mediterranean regions. Syrian rue has been used in Middle Eastern and North African folk medicine and spiritual practices for millennia.
The seeds of the Syrian rue plant are often dried and burnt as incense, with the smoke believed to ward off the evil eye. This practice has been observed in various cultures, including in Yemen, where the Jewish community used the plant in the traditional preparation of unleavened bread for Passover. The process involves bleaching wheat kernels with the astringent leaves of the plant, which are spread in layers over the kernels.
In North America, the plant is commonly referred to as African rue, while other names include harmel (in India, Algeria, and Morocco), wild rue, and mountain rue. The seeds of the plant have also been powdered and used by ancient Greeks to expel parasitic worms and treat recurring fevers.
Today, Syrian rue is still used in incense aromas for soaps, candles, and other products. It is also known to have hallucinogenic properties and has been traditionally used in ceremonies. However, it is considered a potentially dangerous substance due to its MAO inhibitory effects and the risk of serotonin syndrome when combined with certain medications.
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Syrian rue is mentioned in the Quran as a sacred plant, with a long history of ritual and medicinal use
Syrian rue, or Peganum harmala, is a desert plant that grows in the Eastern Mediterranean, throughout the Middle East, and up to India, Mongolia, and Manchuria. It is a perennial, herbaceous plant with a woody underground rootstock, usually growing in saline soils in temperate desert and Mediterranean regions. The plant is commonly known as wild rue, African rue, esfand, or harmel, among other names. Syrian rue has a long history of ritual and medicinal use, with mentions in ancient texts such as Dioscorides' De materia medica and the Quran.
In Islamic traditions and Sufism, Syrian rue is considered a sacred plant. According to a narration attributed to the fourth Imam, Zayn al-‘Abidin, the Prophet said: "The wild rue (al-harmal) does not grow a tree, or a leaf, or a fruit, but that it has an angel in charge of it until it reaches the one who comes to it, or until it becomes debris. In its root and branches is a secret, and in its seed is healing from seventy-two illnesses. So treat yourselves with it and with frankincense." This narration highlights the spiritual significance of Syrian rue in Islam and its perceived healing properties.
The seeds of Syrian rue have been used in both medicinal and spiritual practices for millennia. As early as 60 CE, Dioscorides described the plant's medicinal properties, noting that wild rue mixed with other ingredients was useful for treating weak vision. The ancient Greeks used powdered seeds to expel tapeworms and treat recurring fevers, possibly malaria. Syrian rue was also mentioned by the Greek-Roman physician Galen, who classified the herb as "warm and dry in the third degree." Medieval Arab herbalists used it as an aphrodisiac and to treat epilepsy.
In addition to its medicinal uses, Syrian rue has been employed in rituals and spiritual practices. The smoke from burning Syrian rue is believed to ward off the evil eye. It is also used in Middle Eastern and North African folk medicine and has been applied to treat various ailments, including skin rashes, asthma, and flatulence. The seeds can be used for dyeing, and the stems, roots, and seeds can be used for inks and tattoos. Syrian rue is also used as an incense aroma for soaps, candles, and massage oils.
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The plant is considered a noxious weed in several countries as eating it can sicken or kill livestock
Syrian rue, scientifically known as Peganum harmala, is a perennial, herbaceous plant with a woody underground rootstock. It is native to temperate desert and Mediterranean regions, typically growing in saline soils. Syrian rue has a wide range of traditional and modern uses, from folk medicine to recreational use.
The plant is considered a noxious weed in several countries due to its toxicity to livestock. Eating Syrian rue can sicken or kill livestock, and it has become an invasive species in some regions of the western United States, such as southern New Mexico and the Big Bend region of Texas. Its drought tolerance allows it to outcompete native saltbushes and grasses in the salt-desert shrublands of the Western US.
The toxicity of Syrian rue is a concern for humans as well. While it has been traditionally used as a hallucinogen in ceremonies and for spiritual practices, modern recreational use can lead to adverse effects. Syrian rue is considered a drug of potential abuse due to its sedative and hallucinogenic properties, attributed to its MAO inhibitory effects. Combined intake with DMT, for example, has resulted in MAO-related toxicity, causing adverse events such as bradycardia and hypotension.
Additionally, small doses of Syrian rue seeds can be mildly stimulating but may also act as a depressant. Larger doses can have more potent hallucinogenic effects, and consumption of decoctions made from the seeds has resulted in toxic effects. Histological studies in rats have further shown liver degeneration and negative changes in the CNS (Central Nervous System). Oral doses at 0.15% of an animal's body weight are estimated to be lethal.
Syrian rue has a long history of use in various cultures, including ancient Greece, where it was used to expel parasitic worms and treat recurring fevers. In Yemen, it was used in a traditional Jewish practice to bleach wheat flour for Passover, producing white unleavened bread. It has also been used in Middle Eastern and North African folk medicine, as well as in modern-day products like incense, soaps, and candles.
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Syrian rue is used in candle-making and soaps, and as an analgesic, emmenagogue, and abortifacient agent
Syrian rue, scientifically known as Peganum harmala, is a plant that has been used for centuries in traditional medicine for its potential health benefits. It is native to the Mediterranean region and can also be found in parts of Asia and Africa. Syrian rue is a common ingredient in candle-making and soaps due to its pleasant aroma. Beyond its use in candles and soaps, Syrian rue has been used as an analgesic, emmenagogue, and abortifacient agent.
Analgesic Properties
Syrian rue's active compounds are believed to have analgesic effects by modulating the levels of certain neurotransmitters involved in pain perception. It has been used for pain relief and to treat digestive problems like ulcers and acid reflux.
Emmenagogue and Abortifacient Agent
Syrian rue, or P. harmala, has been traditionally used as an emmenagogue and abortifacient in the Middle East, India, and North Africa. Laboratory studies have shown reductions in reproduction rates in female laboratory rats fed methanol extracts of P. harmala.
Cautions and Adverse Reactions
Syrian rue should be used with caution and only in moderation. It is not recommended for pregnant or breastfeeding women or individuals with certain medical conditions, such as heart disease or schizophrenia. High doses of Syrian rue can cause hallucinations and other mental disturbances due to its psychoactive properties. Adverse reactions, including bradycardia and hypotension, have been documented with the use of Syrian rue.
Other Uses
In addition to its medicinal uses, Syrian rue has been used in spiritual practices and as a psychoactive drug. The ancient Greeks used powdered seeds to treat recurring fevers and tapeworms. In Turkey, the dried capsules are used as a talisman against the "evil eye," and the smoke from burning the dried seeds is used to treat mental illnesses. Syrian rue has also found its way into modern-day recreational use as a hallucinogen in ceremonies.
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Frequently asked questions
Syrian Rue, scientifically known as Peganum Harmala, is a perennial, herbaceous plant with a woody underground rootstock. It is commonly used in Middle Eastern and North African folk medicine.
Syrian Rue has been used in both medicinal and spiritual practices for millennia. It is also used as an incense aroma for soaps and candle-making. Syrian Rue has also been traditionally used as a hallucinogen in ceremonies and for modern-day recreational use.
Syrian Rue is considered a drug with the potential for abuse due to its sedative and hallucinogenic properties. It can cause adverse reactions, including bradycardia and hypotension, and may result in serotonin syndrome if combined with serotonergic agents.
You can find Syrian Rue for sale on websites like Etsy and Fayetteville Herb Co.
In Yemen, for example, the Jewish custom was to use Syrian Rue to bleach wheat kernels and produce unleavened bread for Passover. Syrian Rue is also used in creating the Ayahuasca brew, a traditional ceremonial drink with hallucinogenic properties.











































